|
KMID : 0614620050460020084
|
|
Korean Journal of Gastroenterology
2005 Volume.46 No. 2 p.84 ~ p.93
|
|
|
Expression of Cyclin Dependent Kinase Inhibitors of KIP Family in Gastric Cancer
|
|
Lee Soo-Jung
Joo Young-Eun
Kim Hyun-Soo
Choi Sung-Kyu
Rew Jong-Sun
Park Chang-Soo
Kim Sei-Jong
|
|
|
Abstract
|
|
|
Background/Aims: The cyclin-dependent kinase inhibitors (CDKI) including p21, p27, and p57 of the kinase inhibitor protein (KIP) family are negative regulators of cell cycle progression and potentially act as tumor suppressor. Tumor behavior and growth are influenced by the extent of tumor cell proliferation. The aim of this study was to evaluate the expression of KIP family CDKI in gastric cancer tissue, and to examine the
relationship between these expression and various clinicopathological parameters including tumor cell proliferation.
Methods: We conducted an immunohistochemical analysis of p21, p27, and p57 expression in 109 gastric cancer tissues. Tumor cell proliferation was assessed by immunohistochemistry with antibody against Ki-67.
Results: Negative expression of p21, p27, and p57 was demonstrated in 45.9%, 65.1%, and 57.8% of cancer tissues, respectively. Negative expression of p21 correlated with larger tumor size, poor differentiation, depth of invasion, lymph node metastasis and advanced TNM stage (p=0.048, 0.041, 0.001, 0.005, and 0.001 respectively). Negative
expression of p21 correlated with poor survival (p=0.037). Tumors with negative p21 expression had higher Ki-67 expression than those with positive p21 expression (p=0.024). No significant correlation could be observed between status of p27 and p57 expression and various clinicopathological parameters including survival and tumor
cell proliferation.
Conclusions: These results suggest that negative expression of p21 may play an important role in carcinogenesis by stimulating tumor cell proliferation, and may help in predicting the prognosis of gastric cancer.
|
|
|
KEYWORD
|
|
|
p21, p27, p57, Ki-67 antigen, Gastric cancer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|